Search results for " Biosensing Techniques"

showing 4 items of 4 documents

Current-Driven Organic Electrochemical Transistors for Monitoring Cell Layer Integrity with Enhanced Sensitivity

2021

In this progress report an overview is given on the use of the organic electrochemical transistor (OECT) as a biosensor for impedance sensing of cell layers. The transient OECT current can be used to detect changes in the impedance of the cell layer, as shown by Jimison et al. To circumvent the application of a high gate bias and preventing electrolysis of the electrolyte, in case of small impedance variations, an alternative measuring technique based on an OECT in a current-driven configuration is developed. The ion-sensitivity is larger than 1200 mV V-1 dec-1 at low operating voltage. It can be even further enhanced using an OECT based complementary amplifier, which consists of a p-type a…

Materials scienceTransistors ElectronicBiomedical EngineeringPharmaceutical ScienceElectrolyteBiosensing TechniquesTransistorslaw.inventionBiomaterialsElectrolytesPEDOT:PSSimpedance sensinglawcell layer integrityElectric ImpedanceElectronicPEDOT:PSSHumansElectrical impedanceorganic bioelectronicsElectrolysisbusiness.industryAmplifierTransistorcell layer integrity; impedance sensing; organic bioelectronics; organic electro-chemical transistors; PEDOT:PSS; Caco-2 Cells; Electric Impedance; Electrolytes; Humans; Biosensing Techniques; Transistors ElectronicOptoelectronicsCaco-2 Cellsbusinessorganic electro-chemical transistorsBiosensorOrganic electrochemical transistor
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Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution

2020

Significance Magnetic resonance imaging is hindered by inherently low sensitivity, which limits the method for the most part to observing water molecules in the body. Hyperpolarized molecules exhibit strongly enhanced MRI signals which opens the door for imaging low-concentration species in vivo. Biomolecules can be hyperpolarized and injected into a patient allowing for metabolism to be tracked in real time, greatly expanding the information available to the radiologist. Parahydrogen-induced polarization (PHIP) is a hyperpolarization method renowned for its low cost and accessibility, but is generally limited by low polarization levels, modest molecular concentrations, and contamination by…

Molar concentrationparahydrogen02 engineering and technologyBiosensing Techniques010402 general chemistry01 natural sciencesChemical reaction41003 medical and health sciences0302 clinical medicineFumaratesHyperpolarization (physics)Carbon-13 Magnetic Resonance SpectroscopyPolarization (electrochemistry)DissolutionhyperpolarizationBiomarker; Hyperpolarization; Metabolism; MRI; Parahydrogen; Fumarates; Molecular Imaging; Solutions; Water; Biosensing Techniques; Carbon-13 Magnetic Resonance Spectroscopychemistry.chemical_classificationParahydrogenMultidisciplinaryAqueous solutionChemistryBiomolecule500WaterBiomarker021001 nanoscience & nanotechnologyCombinatorial chemistryMolecular Imaging0104 chemical sciencesSolutionsSolventChemistryHyperpolarizationMetabolism030220 oncology & carcinogenesisReagentPhysical Sciencesbiomarkerddc:5000210 nano-technologymetabolismBiosensorMRI
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Highly selective detection of Epinephrine at oxidized Single-Wall Carbon Nanohorns modified Screen Printed Electrodes (SPEs)

2014

Oxidized Single-Wall Carbon Nanohorns (o-SWCNHs) were used, for the first time, to assemble chemically modified Screen Printed Electrodes (SPEs) selective towards the electrochemical detection of Epinephrine (Ep), in the presence of Serotonine-5-HT (S-5HT), Dopamine (DA), Nor-Epineprhine (Nor-Ep), Ascorbic Acid (AA), Acetaminophen (Ac) and Uric Acid (UA). The Ep neurotransmitter was detected by using Differential Pulse Voltammetry (DPV), in a wide linear range of concentration (2-2500 μM) with high sensitivity (55.77 A M(-1) cm(-2)), very good reproducibility (RSD% ranging from 2 to 10 for different SPEs), short response time for each measurement (only 2s) and low detection of limit (LOD=0.…

Neurotransmitters; Screen Printed Electrodes (SPEs); Selective detection; SWCNHs; Biosensing Techniques; Electrochemical Techniques; Electrodes; Epinephrine; Limit of Detection; Nanostructures; Oxidation-Reduction; Reproducibility of Results; Biophysics; Biomedical Engineering; Biotechnology; Electrochemistry; Medicine (all)NanostructureEpinephrineScreen Printed Electrodes (SPEs)ElectrodeBiophysicsAnalytical chemistryBiomedical EngineeringReproducibility of ResultBiosensing TechniquesElectrochemistryNanomaterialsSWCNHs; Screen Printed Electrodes (SPEs); Neurotransmitters; Selective detectionBiosensing TechniqueSelective detectionLimit of DetectionElectrochemistrySWCNHSettore CHIM/01 - Chimica AnaliticaNeurotransmitterElectrodesDetection limitSWCNHsReproducibilityElectrochemical TechniqueChemistryMedicine (all)Reproducibility of ResultsGeneral MedicineElectrochemical TechniquesNeurotransmittersAscorbic acidNanostructuresLinear rangeBiophysicElectrodeDifferential pulse voltammetryOxidation-ReductionNuclear chemistryBiotechnology
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Green and Integrated Wearable Electrochemical Sensor for Chloride Detection in Sweat

2022

Wearable sensors for sweat biomarkers can provide facile analyte capability and monitoring for several diseases. In this work, a green wearable sensor for sweat absorption and chloride sensing is presented. In order to produce a sustainable device, polylactic acid (PLA) was used for both the substrate and the sweat absorption pad fabrication. The sensor material for chloride detection consisted of silver-based reference, working, and counter electrodes obtained from upcycled compact discs. The PLA substrates were prepared by thermal bonding of PLA sheets obtained via a flat die extruder, prototyped in single functional layers via CO2 laser cutting, and bonded via hot-press. The effect of co…

SilverPolyestersSettore ING-IND/34 - Bioingegneria IndustrialeBiosensing TechniquesElectrochemical TechniquesBiochemistryAtomic and Molecular Physics and OpticsAnalytical ChemistryWearable Electronic DevicesSettore ING-IND/23 - Chimica Fisica ApplicataSettore ING-IND/22 - Scienza E Tecnologia Dei MaterialiChloridesSettore ING-IND/17 - Impianti Industriali MeccaniciHumansElectrical and Electronic Engineeringelectrochemical sensors; wearable sensor; chloride detection; electrolyte assisted electrospinning; environmental-friendly; laser cuttingSweatchloride detection electrochemical sensors electrolyte assisted electrospinning environmental-friendly laser cutting wearable sensor Humans Sweat Chlorides Silver Polyesters Electrochemical Techniques Wearable Electronic Devices Biosensing TechniquesInstrumentation
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